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Synthesis of 5,6-substituted benzimidazoles and their evaluation as potential intermediates in the anaerobic vitamin B12 biosynthesis pathway

Aniket S. R. Vartak, Shashank Verma and Amrita B. Hazra*

Chemical Communications 2024, https://doi.org/10.1039/d4cc04489d

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Efficient Chemical and Enzymatic Syntheses of FAD Nucleobase Analogues and Their Analysis as Enzyme Cofactors

Ateek Shah, Yashwant Kumar, S Rohan, Amrita B. Hazra*

ChemBioChem 2023, https://doi.org/10.1002/cbic.202300055

  Link  Article

Methylations in vitamin B12 biosynthesis and catalysis

Yamini Mathur, Amrita B. Hazra*

Current Opinion in Structural Biology, 2022, https://doi.org/10.1016/j.sbi.2022.102490

  Link  Article

Exchange of Vitamin B1 and Its Biosynthesis Intermediates Shapes the Composition of Synthetic Microbial Cocultures and Reveals Complexities of Nutrient Sharing

Rupali R.M. Sathe, Ryan Paerl, Amrita B. Hazra*

Journal of Bacteriology, 2022, https://doi.org/10.1128/jb.00503-21

  Link  Article

Guardian of cobamide diversity: Probing the role of CobT in lower ligand activation in the biosynthesis of vitamin B12 and other cobamide cofactors

Yamini Mathur, Aniket R. Vartak, Amrita B. Hazra*

Methods in Enzymology: B12 Enzymes

  Link  Article

Leveraging an enzyme/artificial substrate system to enhance cellular persulfides and mitigate neuroinflammation.
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Prerona Bora, Suman Manna S, Mrutyunjay A Nair, Rupali R.M. Sathe, Shubham Singh, Venkata Sai Sreyas Adury, Kavya Gupta, Arnab Mukherjee, Deepak K. Saini, Siddhesh S. Kamat, Amrita B. Hazra*, Harinath Chakrapani*

Chem Sci. 2021 Aug 24;12(39):12939-12949. doi: 10.1039/d1sc03828a.

  Link  Article

CTP dependent Riboflavin kinase from mesophilic archaea

Characterization of a novel mesophilic CTP-dependent riboflavin kinase and rational engineering to create its thermostable homologs

Yashwant Kumar, Reman Kumar Singh*, Amrita B. Hazra*

ChemBioChem 2021, Accepted Article, DOI: 10.1002/cbic.202100211

  Link  Article

Auxin biosynthesis in pathogenic Pseudomonas syringae bacterium

Double agent indole-3-acetic acid (IAA): Mechanistic analysis of indole-3-acetaldehyde dehydrogenase AldA that synthesizes IAA, an auxin that aids bacterial virulence

Ateek Shah, Yamini Mathur, Amrita B. Hazra*

Bioscience Reports 2021, DOI: 10.1042/BSR20210598 

  Link  Article

Vitamin B12 biosynthesis in anaerobic

CobT and BzaC catalyze the regiospecific activation and methylation of the 5-hydroxybenzimidazole lower ligand in anaerobic cobamide biosynthesis

Yamini Mathur, Shreyl Sreyas, Prathamesh M. Datar, Majima B. Sathian, Amrita B. Hazra*

J Biol Chem 2020, 295(31), 1052 

  Link  Article

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Biodegradable Polymer Theranostic Fluorescent Nanoprobe for Direct Visualization and Quantitative Determination of Antimicrobial Activity

Ruma Ghosh, Mehak Malhotra, Rupali Ravindra Madhuri Sathe, Manickam Jayakannan*

ACS Biomacromolecules  2020, 21, 7, 2896–2912

  Link  Article

Vitamin B12 biosynthesis, BluB, DMB

Unique Biochemical and Sequence Features Enable BluB To Destroy Flavin and Distinguish BluB from the Flavin Monooxygenase Superfamily

Amrita B. Hazra, David P. Ballou*, and Michiko E. Taga*

Biochemistry 2018, 57 (11), 1748

Link   Article

Anaerobic biosynthesis of the lower ligand of Vitamin B12

Amrita B. Hazra, Andrew W. Han, Angad P. Mehta, Kenny C. Mok, Vadim Osadchiy, Tadhg P. Begley, and Michiko E. Taga

Proc Natl Acad Sci USA 2015, 112 (34), 10792.

Link   Article

Vitamin B1 biosynthesis, Thiamin, ThiC

Anaerobic 5-Hydroxybenzimidazole Formation from Aminoimidazole Ribotide: An Unanticipated Intersection of Thiamin and Vitamin B12 Biosynthesis.

Angad P. Mehta​, Sameh H. Abdelwahed,  Michael K. Fenwick, Amrita B. Hazra, 

Michiko E. Taga,​ Yang Zhang, Steven E. Ealick, Tadhg P. Begley

J. Am. Chem. Soc. 2015, 137 (33), 10444

Link   Article

Mechanisms of direct inhibition of the respiratory sulfate-reduction pathway by (per)chlorate and nitrate.

Hans K Carlson, Jennifer V Kuehl, Amrita B Hazra, Nicholas B Justice, Magdalena K Stoeva, Andrew Sczesnak, Mark R Mullan, Anthony T Iavarone, Anna Engelbrektson, Morgan N Price, Adam M Deutschbauer, Adam P Arkin & John D Coates

ISME J. 2014, No. 10, 1295.

Link   Article

Vitamin B12 biosynthesis, CobT, phosphoribosyltransferase

Regiospecific Formation of Cobamide Isomers Is Directed by CobT

Terence S. Crofts, Amrita B. Hazra, Jennifer LA Tran, Olga M. Sokolovskaya, 

Vadim Osadchiy, Omer Ad, Jeffrey Pelton, Stefan Bauer, and Michiko E. Taga

Biochemistry 2014, 53 (49), 7805.

Link  Article

Vitamin B12 biosynthesis, CobT, phosphoribosyltransferase

Cobamide Structure Depends on Both Lower Ligand Availability and CobT Substrate Specificity

Terence S. Crofts, Erica C. Seth, Amrita B. Hazra, Michiko E. Taga

Chem. Biol. 2013, 20 (10), 1265

Link  Article

Vitamin B12 biosynthesis, CobT, phosphoribosyltransferase

Analysis of Substrate Specificity in CobT Homologs Reveals Widespread Preference for DMB, the Lower Axial Ligand of Vitamin B12

Amrita B. Hazra, Jennifer L.A. Tran, Terence S. Crofts, Michiko E. Taga

Chem. Biol. 2013, 20 (10), 1265.

Link  Article

Vitamin B1 biosynthesis

Thiamin Pyrimidine Biosynthesis in Candida albicans: A Remarkable Reaction between Histidine and Pyridoxal Phosphate

Rung-Yi Lai, Siyu Huang, Michael K. Fenwick, Amrita Hazra, Yang Zhang, Kanagalaghatta Rajashankar, Benjamin Philmus, Cynthia Kinsland, Jennie Mansell Sanders, Steven E. Ealick*, and Tadhg P. Begley*

J. Am Chem Soc. 2012 , 134 (22), 9157.

Link  Article

Vitamin B1 biosynthesis

A "Radical Dance" in Thiamin Biosynthesis: Mechanistic Analysis of the Bacterial Hydroxymethylpyrimidine Phosphate Synthase.

Abhishek Chatterjee, Amrita B. Hazra, Sameh Abdelwahed, David G. Hilmey, and  Tadhg P. Begley*

Angew. Chemie - Int. Ed. 2010, 49 (46), 8653.

Link  Article

Biosynthesis of the Thiamin Thiazole in Bacillus subtilis: Identification of the Product of the Thiazole Synthase-Catalyzed Reaction

Vitamin B12 biosynthesis

Amrita B. Hazra, Abhishek Chatterjee, and  Tadhg P. Begley*

J. Am. Chem. Soc. 2009, 131 (9), 3225.

Link  Article

Cofactor biosynthesis-still yielding fascinating new biological chemistry

Tadhg P Begley*, Abhishek Chatterjee, Jeremiah W Hanes, Amrita B Hazra, and Steven E Ealick

Curr Opin Chem Biol.2008, 12(2), 118.

Link Article

Chemistry of enediynyl azides:activation through a novel pathway

Amit Basak*, Sandip K. Roy, Sanket Das, Amrita B. Hazra, Subhash C. Ghosh, and Shailendra Jha

Chem Commun 2007, No. 6, 622.

Link  Article

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