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Efficient Chemical and Enzymatic Syntheses of FAD Nucleobase Analogues and Their Analysis as Enzyme Cofactors

Ateek Shah, Yashwant Kumar, S Rohan, Amrita B. Hazra*

ChemBioChem 2023, https://doi.org/10.1002/cbic.202300055

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Methylations in vitamin B12 biosynthesis and catalysis

Yamini Mathur, Amrita B. Hazra*

Current Opinion in Structural Biology, 2022, https://doi.org/10.1016/j.sbi.2022.102490

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Exchange of Vitamin B1 and Its Biosynthesis Intermediates Shapes the Composition of Synthetic Microbial Cocultures and Reveals Complexities of Nutrient Sharing

Rupali R.M. Sathe, Ryan Paerl, Amrita B. Hazra*

Journal of Bacteriology, 2022, https://doi.org/10.1128/jb.00503-21

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Guardian of cobamide diversity: Probing the role of CobT in lower ligand activation in the biosynthesis of vitamin B12 and other cobamide cofactors

Yamini Mathur, Aniket R. Vartak, Amrita B. Hazra*

Methods in Enzymology: B12 Enzymes

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Leveraging an enzyme/artificial substrate system to enhance cellular persulfides and mitigate neuroinflammation.

Prerona Bora, Suman Manna S, Mrutyunjay A Nair, Rupali R.M. Sathe, Shubham Singh, Venkata Sai Sreyas Adury, Kavya Gupta, Arnab Mukherjee, Deepak K. Saini, Siddhesh S. Kamat, Amrita B. Hazra*, Harinath Chakrapani*

Chem Sci. 2021 Aug 24;12(39):12939-12949. doi: 10.1039/d1sc03828a.

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CTP dependent Riboflavin kinase from mesophilic archaea

Characterization of a novel mesophilic CTP-dependent riboflavin kinase and rational engineering to create its thermostable homologs

Yashwant Kumar, Reman Kumar Singh*, Amrita B. Hazra*

ChemBioChem 2021, Accepted Article, DOI: 10.1002/cbic.202100211

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Auxin biosynthesis in pathogenic Pseudomonas syringae bacterium

Double agent indole-3-acetic acid (IAA): Mechanistic analysis of indole-3-acetaldehyde dehydrogenase AldA that synthesizes IAA, an auxin that aids bacterial virulence

Ateek Shah, Yamini Mathur, Amrita B. Hazra*

Bioscience Reports 2021, DOI: 10.1042/BSR20210598

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CobT and BzaC catalyze the regiospecific activation and methylation of the 5-hydroxybenzimidazole lower ligand in anaerobic cobamide biosynthesis

Yamini Mathur, Shreyl Sreyas, Prathamesh M. Datar, Majima B. Sathian, Amrita B. Hazra*

J Biol Chem 2020, 295(31), 1052

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Biodegradable Polymer Theranostic Fluorescent Nanoprobe for Direct Visualization and Quantitative Determination of Antimicrobial Activity

Ruma Ghosh, Mehak Malhotra, Rupali Ravindra Madhuri Sathe, Manickam Jayakannan*

ACS Biomacromolecules 2020, 21, 7, 2896–2912

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Unique Biochemical and Sequence Features Enable BluB To Destroy Flavin and Distinguish BluB from the Flavin Monooxygenase Superfamily

Amrita B. Hazra, David P. Ballou*, and Michiko E. Taga*

Biochemistry 2018, 57 (11), 1748

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Anaerobic biosynthesis of the lower ligand of Vitamin B12

Amrita B. Hazra, Andrew W. Han, Angad P. Mehta, Kenny C. Mok, Vadim Osadchiy, Tadhg P. Begley, and Michiko E. Taga

Proc Natl Acad Sci USA 2015, 112 (34), 10792.

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Anaerobic 5-Hydroxybenzimidazole Formation from Aminoimidazole Ribotide: An Unanticipated Intersection of Thiamin and Vitamin B12 Biosynthesis.

Angad P. Mehta, Sameh H. Abdelwahed, Michael K. Fenwick, Amrita B. Hazra,

Michiko E. Taga, Yang Zhang, Steven E. Ealick, Tadhg P. Begley

J. Am. Chem. Soc. 2015, 137 (33), 10444

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Mechanisms of direct inhibition of the respiratory sulfate-reduction pathway by (per)chlorate and nitrate.

Hans K Carlson, Jennifer V Kuehl, Amrita B Hazra, Nicholas B Justice, Magdalena K Stoeva, Andrew Sczesnak, Mark R Mullan, Anthony T Iavarone, Anna Engelbrektson, Morgan N Price, Adam M Deutschbauer, Adam P Arkin & John D Coates

ISME J. 2014, No. 10, 1295.

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Vitamin B12 biosynthesis, CobT, phosphoribosyltransferase

Regiospecific Formation of Cobamide Isomers Is Directed by CobT

Terence S. Crofts, Amrita B. Hazra, Jennifer LA Tran, Olga M. Sokolovskaya,

Vadim Osadchiy, Omer Ad, Jeffrey Pelton, Stefan Bauer, and Michiko E. Taga

Biochemistry 2014, 53 (49), 7805.

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Cobamide Structure Depends on Both Lower Ligand Availability and CobT Substrate Specificity

Terence S. Crofts, Erica C. Seth, Amrita B. Hazra, Michiko E. Taga

Chem. Biol. 2013, 20 (10), 1265

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Analysis of Substrate Specificity in CobT Homologs Reveals Widespread Preference for DMB, the Lower Axial Ligand of Vitamin B12

Amrita B. Hazra, Jennifer L.A. Tran, Terence S. Crofts, Michiko E. Taga

Chem. Biol. 2013, 20 (10), 1265.

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Thiamin Pyrimidine Biosynthesis in Candida albicans: A Remarkable Reaction between Histidine and Pyridoxal Phosphate

Rung-Yi Lai, Siyu Huang, Michael K. Fenwick, Amrita Hazra, Yang Zhang, Kanagalaghatta Rajashankar, Benjamin Philmus, Cynthia Kinsland, Jennie Mansell Sanders, Steven E. Ealick*, and Tadhg P. Begley*

J. Am Chem Soc. 2012 , 134 (22), 9157.

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A "Radical Dance" in Thiamin Biosynthesis: Mechanistic Analysis of the Bacterial Hydroxymethylpyrimidine Phosphate Synthase.

Abhishek Chatterjee, Amrita B. Hazra, Sameh Abdelwahed, David G. Hilmey, and Tadhg P. Begley*

Angew. Chemie - Int. Ed. 2010, 49 (46), 8653.

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Biosynthesis of the Thiamin Thiazole in Bacillus subtilis: Identification of the Product of the Thiazole Synthase-Catalyzed Reaction

Amrita B. Hazra, Abhishek Chatterjee, and Tadhg P. Begley*

J. Am. Chem. Soc. 2009, 131 (9), 3225.

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Cofactor biosynthesis-still yielding fascinating new biological chemistry

Tadhg P Begley*, Abhishek Chatterjee, Jeremiah W Hanes, Amrita B Hazra, and Steven E Ealick

Curr Opin Chem Biol.2008, 12(2), 118.

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Chemistry of enediynyl azides:activation through a novel pathway.

Amit Basak*, Sandip K. Roy, Sanket Das, Amrita B. Hazra, Subhash C. Ghosh, and Shailendra Jha

Chem Commun 2007, No. 6, 622.

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Efficient Chemical and Enzymatic Syntheses of FAD Nucleobase Analogues and Their Analysis as Enzyme Cofactors

Methylations in vitamin B12 biosynthesis and catalysis

Exchange of Vitamin B1 and Its Biosynthesis Intermediates Shapes the Composition of Synthetic Microbial Cocultures and Reveals Complexities of Nutrient Sharing

Guardian of cobamide diversity: Probing the role of CobT in lower ligand activation in the biosynthesis of vitamin B12 and other cobamide cofactors

Leveraging an enzyme/artificial substrate system to enhance cellular persulfides and mitigate neuroinflammation. ​

Characterization of a novel mesophilic CTP-dependent riboflavin kinase and rational engineering to create its thermostable homologs

Double agent indole-3-acetic acid (IAA): Mechanistic analysis of indole-3-acetaldehyde dehydrogenase AldA that synthesizes IAA, an auxin that aids bacterial virulence

CobT and BzaC catalyze the regiospecific activation and methylation of the 5-hydroxybenzimidazole lower ligand in anaerobic cobamide biosynthesis

Biodegradable Polymer Theranostic Fluorescent Nanoprobe for Direct Visualization and Quantitative Determination of Antimicrobial Activity

Unique Biochemical and Sequence Features Enable BluB To Destroy Flavin and Distinguish BluB from the Flavin Monooxygenase Superfamily

Anaerobic biosynthesis of the lower ligand of Vitamin B12

Anaerobic 5-Hydroxybenzimidazole Formation from Aminoimidazole Ribotide: An Unanticipated Intersection of Thiamin and Vitamin B12 Biosynthesis.

Mechanisms of direct inhibition of the respiratory sulfate-reduction pathway by (per)chlorate and nitrate.

Regiospecific Formation of Cobamide Isomers Is Directed by CobT

Cobamide Structure Depends on Both Lower Ligand Availability and CobT Substrate Specificity

Analysis of Substrate Specificity in CobT Homologs Reveals Widespread Preference for DMB, the Lower Axial Ligand of Vitamin B12

Thiamin Pyrimidine Biosynthesis in Candida albicans: A Remarkable Reaction between Histidine and Pyridoxal Phosphate

A "Radical Dance" in Thiamin Biosynthesis: Mechanistic Analysis of the Bacterial Hydroxymethylpyrimidine Phosphate Synthase.

Biosynthesis of the Thiamin Thiazole in Bacillus subtilis: Identification of the Product of the Thiazole Synthase-Catalyzed Reaction

Cofactor biosynthesis-still yielding fascinating new biological chemistry

Chemistry of enediynyl azides:activation through a novel pathway.

Leveraging an enzyme/artificial substrate system to enhance cellular persulfides and mitigate neuroinflammation.